"For example, chronic stress could lead to a hyperactive brain-body circuit that eventually burns the system out and prevents it from adjusting itself in an effective and optimal way," Romo-Nava said. While major depressive disorder can have many different causes, one contributor could be this pathway being overloaded with information. When functioning properly, the brain uses this information to constantly make adjustments to help regulate a person's mood. Romo-Nava said pathways of neurons located in the spinal cord convey information from the body to regions of the brain that are involved in the emotional experience we know as mood. "Many of the symptoms of mood disorders or eating disorders or anxiety disorders have to do with what one could interpret as dysregulation in this brain-body interaction." "We think that the connection between the brain and the body is essential for psychiatric disorders," said Romo-Nava, associate professor in the Department of Psychiatry and Behavioral Neurosciences at UC, associate chief research officer for the Research Institute at the Lindner Center of HOPE and a UC Health physician scientist. Principal investigator Francisco Romo-Nava, MD, PhD, said his research focuses on how brain-body communication is involved in psychiatric disorders. The results of the trial were published in the journal Molecular Psychiatry on Dec.
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